The metric properties of a novel non-motor symptoms scale for parkinson's disease : Results from an international pilot study
Identifieur interne : 003070 ( Main/Exploration ); précédent : 003069; suivant : 003071The metric properties of a novel non-motor symptoms scale for parkinson's disease : Results from an international pilot study
Auteurs : Kallol Ray Chaudhuri [Royaume-Uni] ; Pablo Martinez-Martin [Espagne] ; Richard G. Brown [Royaume-Uni] ; Kapil Sethi [États-Unis] ; Fabrizio Stocchi [Italie] ; Per Odin [Allemagne] ; William Ondo [États-Unis] ; Kazu Abe [Japon] ; Graeme Macphee [Royaume-Uni] ; Doug Macmahon [Royaume-Uni] ; Paolo Barone [Italie] ; Martin Rabey [Israël] ; Alison Forbes ; Kieran Breen [Royaume-Uni] ; Susanne Tluk [Royaume-Uni] ; Yogini Naidu [Royaume-Uni] ; Warren Olanow [États-Unis] ; Adrian J. Williams [Royaume-Uni] ; Sue Thomas [Royaume-Uni] ; David Rye [États-Unis] ; Yoshio Tsuboi [Japon] ; Annette Hand [Royaume-Uni] ; Anthony H. V. Schapira [Royaume-Uni]Source :
- Movement disorders [ 0885-3185 ] ; 2007.
Descripteurs français
- Pascal (Inist)
English descriptors
Abstract
Non-motor symptoms (NMS) in Parkinson's disease (PD) are common, significantly reduce quality of life and at present there is no validated clinical tool to assess the progress or potential response to treatment of NMS. A new 30-item scale for the assessment of NMS in PD (NMSS) was developed. NMSS contains nine dimensions: cardiovascular, sleep/fatigue, mood/cognition, perceptual problems, attention/memory, gastrointestinal, urinary, sexual function, and miscellany. The metric attributes of this instrument were analyzed. Data from 242 patients mean age 67.2 ±11 years, duration of disease 6.4 ± 6 years, and 57.3% male across all stages of PD were collected from the centers in Europe, USA, and Japan. The mean NMSS score was 56.5 ± 40.7, (range: 0-243) and only one declared no NMS. The scale provided 99.2% complete data for the analysis with the total score being free of floor and ceiling effect. Satisfactory scaling assumptions (multitrait scaling success rate >95% for all domains except miscellany) and internal consistency were reported for most of the domains (mean a, 0.61). Factor analysis supported the a prori nine domain structure (63% of the variance) while a small test-retest study showed satisfactory reproducibility (ICC > 0.80) for all domains except cardiovascular (ICC = 0.45). In terms of validity, the scale showed modest association with indicators of motor symptom severity and disease progression but a high correlation with other measures of NMS (NMSQuest) and health-related quality of life measure (PDQ-8) (both, rS = 0.70). In conclusion, NMSS can be used to assess the frequency and severity of NMS in PD patients across all stages in conjunction with the recently validated non-motor questionnaire.
Affiliations:
- Allemagne, Espagne, Israël, Italie, Japon, Royaume-Uni, États-Unis
- Angleterre, Communauté de Madrid, Grand Londres, Géorgie (États-Unis), Latium, Texas, État de New York
- Londres, Madrid, Rome
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Brown</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Department of Psychology, Institute of Psychiatry, King's College London</s1><s2>London</s2><s3>GBR</s3><sZ>3 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Sethi, Kapil" sort="Sethi, Kapil" uniqKey="Sethi K" first="Kapil" last="Sethi">Kapil Sethi</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Neurology, Medical College of Georgia</s1><s3>USA</s3><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Department of Neurology, Medical College of Georgia</wicri:noRegion></affiliation></author><author><name sortKey="Stocchi, Fabrizio" sort="Stocchi, Fabrizio" uniqKey="Stocchi F" first="Fabrizio" last="Stocchi">Fabrizio Stocchi</name><affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Department of Neurology, IRCCS San Rajfaele</s1><s2>Pisana, Roma</s2><s3>ITA</s3><sZ>5 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Odin, Per" sort="Odin, Per" uniqKey="Odin P" first="Per" last="Odin">Per Odin</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Department of Neurology, Klinikum-Bremerhaven Reinkenheide</s1><s2>Bremerhaven</s2><s3>DEU</s3><sZ>6 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Bremerhaven</wicri:noRegion><wicri:noRegion>Klinikum-Bremerhaven Reinkenheide</wicri:noRegion><wicri:noRegion>Bremerhaven</wicri:noRegion></affiliation></author><author><name sortKey="Ondo, William" sort="Ondo, William" uniqKey="Ondo W" first="William" last="Ondo">William Ondo</name><affiliation wicri:level="2"><inist:fA14 i1="09"><s1>Department of Neurology, Baylor College of Medicine</s1><s2>Houston, Texas</s2><s3>USA</s3><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Abe, Kazu" sort="Abe, Kazu" uniqKey="Abe K" first="Kazu" last="Abe">Kazu Abe</name><affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Department of Neurology, Osaka University Graduate School of Medicine</s1><s2>Osaka</s2><s3>JPN</s3><sZ>8 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Osaka</wicri:noRegion></affiliation></author><author><name sortKey="Macphee, Graeme" sort="Macphee, Graeme" uniqKey="Macphee G" first="Graeme" last="Macphee">Graeme Macphee</name><affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Medicine for the Elderly, Southern General Hospital</s1><s2>Glasgow</s2><s3>GBR</s3><sZ>9 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Glasgow</wicri:noRegion></affiliation></author><author><name sortKey="Macmahon, Doug" sort="Macmahon, Doug" uniqKey="Macmahon D" first="Doug" last="Macmahon">Doug Macmahon</name><affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Medicine for Care of Elderly, Camborne-Redruth Hospital</s1><s2>Redruth, Cornwall</s2><s3>GBR</s3><sZ>10 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Redruth, Cornwall</wicri:noRegion></affiliation></author><author><name sortKey="Barone, Paolo" sort="Barone, Paolo" uniqKey="Barone P" first="Paolo" last="Barone">Paolo Barone</name><affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Department of Neurological Sciences, University of Napoli</s1><s2>Napoli</s2><s3>ITA</s3><sZ>11 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Napoli</wicri:noRegion></affiliation></author><author><name sortKey="Rabey, Martin" sort="Rabey, Martin" uniqKey="Rabey M" first="Martin" last="Rabey">Martin Rabey</name><affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Department of Neurology, Assaf Harofeh Medical Center, School of Medicine, Tel-Aviv University</s1><s2>Zerifin</s2><s3>ISR</s3><sZ>12 aut.</sZ></inist:fA14><country>Israël</country><wicri:noRegion>Zerifin</wicri:noRegion></affiliation></author><author><name sortKey="Forbes, Alison" sort="Forbes, Alison" uniqKey="Forbes A" first="Alison" last="Forbes">Alison Forbes</name></author><author><name sortKey="Breen, Kieran" sort="Breen, Kieran" uniqKey="Breen K" first="Kieran" last="Breen">Kieran Breen</name><affiliation wicri:level="3"><inist:fA14 i1="15"><s1>Research and Development Department, The UK Parkinson's Disease Society</s1><s2>London</s2><s3>GBR</s3><sZ>14 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Tluk, Susanne" sort="Tluk, Susanne" uniqKey="Tluk S" first="Susanne" last="Tluk">Susanne Tluk</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Neurology, University Hospital Lewisham</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Naidu, Yogini" sort="Naidu, Yogini" uniqKey="Naidu Y" first="Yogini" last="Naidu">Yogini Naidu</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Neurology, University Hospital Lewisham</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Olanow, Warren" sort="Olanow, Warren" uniqKey="Olanow W" first="Warren" last="Olanow">Warren Olanow</name><affiliation wicri:level="2"><inist:fA14 i1="16"><s1>Department of Neurology, The Mount Sinai School of Medicine</s1><s2>New York</s2><s3>USA</s3><sZ>17 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Williams, Adrian J" sort="Williams, Adrian J" uniqKey="Williams A" first="Adrian J." last="Williams">Adrian J. Williams</name><affiliation wicri:level="3"><inist:fA14 i1="17"><s1>Lane Fox Sleep Centre, St. Thomas' Hospital</s1><s2>London</s2><s3>GBR</s3><sZ>18 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Thomas, Sue" sort="Thomas, Sue" uniqKey="Thomas S" first="Sue" last="Thomas">Sue Thomas</name><affiliation wicri:level="3"><inist:fA14 i1="18"><s1>Policy Advice, Royal College of Nursing</s1><s2>London</s2><s3>GBR</s3><sZ>19 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Rye, David" sort="Rye, David" uniqKey="Rye D" first="David" last="Rye">David Rye</name><affiliation wicri:level="2"><inist:fA14 i1="19"><s1>Department of Neurology, Emory University</s1><s2>Atlanta, Georgia</s2><s3>USA</s3><sZ>20 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Tsuboi, Yoshio" sort="Tsuboi, Yoshio" uniqKey="Tsuboi Y" first="Yoshio" last="Tsuboi">Yoshio Tsuboi</name><affiliation wicri:level="1"><inist:fA14 i1="20"><s1>ifth Department of Internal Medicine, Fukuoka University</s1><s2>Fukuoka</s2><s3>JPN</s3><sZ>21 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Fukuoka</wicri:noRegion></affiliation></author><author><name sortKey="Hand, Annette" sort="Hand, Annette" uniqKey="Hand A" first="Annette" last="Hand">Annette Hand</name><affiliation wicri:level="1"><inist:fA14 i1="21"><s1>Department of Medicine, North Tyneside General Hospital</s1><s2>North Shields</s2><s3>GBR</s3><sZ>22 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>North Shields</wicri:noRegion></affiliation></author><author><name sortKey="Schapira, Anthony H V" sort="Schapira, Anthony H V" uniqKey="Schapira A" first="Anthony H. V." last="Schapira">Anthony H. V. Schapira</name><affiliation wicri:level="3"><inist:fA14 i1="22"><s1>Department of Clinical Neuroscience, Royal Free Hospital Medical School</s1><s2>London</s2><s3>GBR</s3><sZ>23 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="23"><s1>National Hospital for Neurology and Neurosurgery</s1><s2>London</s2><s3>GBR</s3><sZ>23 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">08-0015790</idno><date when="2007">2007</date><idno type="stanalyst">PASCAL 08-0015790 INIST</idno><idno type="RBID">Pascal:08-0015790</idno><idno type="wicri:Area/PascalFrancis/Corpus">001511</idno><idno type="wicri:Area/PascalFrancis/Curation">001808</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">001425</idno><idno type="wicri:doubleKey">0885-3185:2007:Ray Chaudhuri K:the:metric:properties</idno><idno type="wicri:Area/Main/Merge">004015</idno><idno type="wicri:Area/Main/Curation">003070</idno><idno type="wicri:Area/Main/Exploration">003070</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">The metric properties of a novel non-motor symptoms scale for parkinson's disease : Results from an international pilot study</title><author><name sortKey="Ray Chaudhuri, Kallol" sort="Ray Chaudhuri, Kallol" uniqKey="Ray Chaudhuri K" first="Kallol" last="Ray Chaudhuri">Kallol Ray Chaudhuri</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Nationial Parkinson Foundation Centre of Excellence, Kings Collge Hospital,</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Kings College, Institute of Psychiatry</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Neurology, University Hospital Lewisham</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Martinez Martin, Pablo" sort="Martinez Martin, Pablo" uniqKey="Martinez Martin P" first="Pablo" last="Martinez-Martin">Pablo Martinez-Martin</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Unit of Neuroepidemiology, National Center for Epidemiology, Carlos III Institute of Health</s1><s2>Madrid</s2><s3>ESP</s3><sZ>2 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Brown, Richard G" sort="Brown, Richard G" uniqKey="Brown R" first="Richard G." last="Brown">Richard G. Brown</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Department of Psychology, Institute of Psychiatry, King's College London</s1><s2>London</s2><s3>GBR</s3><sZ>3 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Sethi, Kapil" sort="Sethi, Kapil" uniqKey="Sethi K" first="Kapil" last="Sethi">Kapil Sethi</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Neurology, Medical College of Georgia</s1><s3>USA</s3><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Department of Neurology, Medical College of Georgia</wicri:noRegion></affiliation></author><author><name sortKey="Stocchi, Fabrizio" sort="Stocchi, Fabrizio" uniqKey="Stocchi F" first="Fabrizio" last="Stocchi">Fabrizio Stocchi</name><affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Department of Neurology, IRCCS San Rajfaele</s1><s2>Pisana, Roma</s2><s3>ITA</s3><sZ>5 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Odin, Per" sort="Odin, Per" uniqKey="Odin P" first="Per" last="Odin">Per Odin</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Department of Neurology, Klinikum-Bremerhaven Reinkenheide</s1><s2>Bremerhaven</s2><s3>DEU</s3><sZ>6 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Bremerhaven</wicri:noRegion><wicri:noRegion>Klinikum-Bremerhaven Reinkenheide</wicri:noRegion><wicri:noRegion>Bremerhaven</wicri:noRegion></affiliation></author><author><name sortKey="Ondo, William" sort="Ondo, William" uniqKey="Ondo W" first="William" last="Ondo">William Ondo</name><affiliation wicri:level="2"><inist:fA14 i1="09"><s1>Department of Neurology, Baylor College of Medicine</s1><s2>Houston, Texas</s2><s3>USA</s3><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Abe, Kazu" sort="Abe, Kazu" uniqKey="Abe K" first="Kazu" last="Abe">Kazu Abe</name><affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Department of Neurology, Osaka University Graduate School of Medicine</s1><s2>Osaka</s2><s3>JPN</s3><sZ>8 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Osaka</wicri:noRegion></affiliation></author><author><name sortKey="Macphee, Graeme" sort="Macphee, Graeme" uniqKey="Macphee G" first="Graeme" last="Macphee">Graeme Macphee</name><affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Medicine for the Elderly, Southern General Hospital</s1><s2>Glasgow</s2><s3>GBR</s3><sZ>9 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Glasgow</wicri:noRegion></affiliation></author><author><name sortKey="Macmahon, Doug" sort="Macmahon, Doug" uniqKey="Macmahon D" first="Doug" last="Macmahon">Doug Macmahon</name><affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Medicine for Care of Elderly, Camborne-Redruth Hospital</s1><s2>Redruth, Cornwall</s2><s3>GBR</s3><sZ>10 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Redruth, Cornwall</wicri:noRegion></affiliation></author><author><name sortKey="Barone, Paolo" sort="Barone, Paolo" uniqKey="Barone P" first="Paolo" last="Barone">Paolo Barone</name><affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Department of Neurological Sciences, University of Napoli</s1><s2>Napoli</s2><s3>ITA</s3><sZ>11 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Napoli</wicri:noRegion></affiliation></author><author><name sortKey="Rabey, Martin" sort="Rabey, Martin" uniqKey="Rabey M" first="Martin" last="Rabey">Martin Rabey</name><affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Department of Neurology, Assaf Harofeh Medical Center, School of Medicine, Tel-Aviv University</s1><s2>Zerifin</s2><s3>ISR</s3><sZ>12 aut.</sZ></inist:fA14><country>Israël</country><wicri:noRegion>Zerifin</wicri:noRegion></affiliation></author><author><name sortKey="Forbes, Alison" sort="Forbes, Alison" uniqKey="Forbes A" first="Alison" last="Forbes">Alison Forbes</name></author><author><name sortKey="Breen, Kieran" sort="Breen, Kieran" uniqKey="Breen K" first="Kieran" last="Breen">Kieran Breen</name><affiliation wicri:level="3"><inist:fA14 i1="15"><s1>Research and Development Department, The UK Parkinson's Disease Society</s1><s2>London</s2><s3>GBR</s3><sZ>14 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Tluk, Susanne" sort="Tluk, Susanne" uniqKey="Tluk S" first="Susanne" last="Tluk">Susanne Tluk</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Neurology, University Hospital Lewisham</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Naidu, Yogini" sort="Naidu, Yogini" uniqKey="Naidu Y" first="Yogini" last="Naidu">Yogini Naidu</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Neurology, University Hospital Lewisham</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Olanow, Warren" sort="Olanow, Warren" uniqKey="Olanow W" first="Warren" last="Olanow">Warren Olanow</name><affiliation wicri:level="2"><inist:fA14 i1="16"><s1>Department of Neurology, The Mount Sinai School of Medicine</s1><s2>New York</s2><s3>USA</s3><sZ>17 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Williams, Adrian J" sort="Williams, Adrian J" uniqKey="Williams A" first="Adrian J." last="Williams">Adrian J. Williams</name><affiliation wicri:level="3"><inist:fA14 i1="17"><s1>Lane Fox Sleep Centre, St. Thomas' Hospital</s1><s2>London</s2><s3>GBR</s3><sZ>18 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Thomas, Sue" sort="Thomas, Sue" uniqKey="Thomas S" first="Sue" last="Thomas">Sue Thomas</name><affiliation wicri:level="3"><inist:fA14 i1="18"><s1>Policy Advice, Royal College of Nursing</s1><s2>London</s2><s3>GBR</s3><sZ>19 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Rye, David" sort="Rye, David" uniqKey="Rye D" first="David" last="Rye">David Rye</name><affiliation wicri:level="2"><inist:fA14 i1="19"><s1>Department of Neurology, Emory University</s1><s2>Atlanta, Georgia</s2><s3>USA</s3><sZ>20 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Tsuboi, Yoshio" sort="Tsuboi, Yoshio" uniqKey="Tsuboi Y" first="Yoshio" last="Tsuboi">Yoshio Tsuboi</name><affiliation wicri:level="1"><inist:fA14 i1="20"><s1>ifth Department of Internal Medicine, Fukuoka University</s1><s2>Fukuoka</s2><s3>JPN</s3><sZ>21 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Fukuoka</wicri:noRegion></affiliation></author><author><name sortKey="Hand, Annette" sort="Hand, Annette" uniqKey="Hand A" first="Annette" last="Hand">Annette Hand</name><affiliation wicri:level="1"><inist:fA14 i1="21"><s1>Department of Medicine, North Tyneside General Hospital</s1><s2>North Shields</s2><s3>GBR</s3><sZ>22 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>North Shields</wicri:noRegion></affiliation></author><author><name sortKey="Schapira, Anthony H V" sort="Schapira, Anthony H V" uniqKey="Schapira A" first="Anthony H. V." last="Schapira">Anthony H. V. Schapira</name><affiliation wicri:level="3"><inist:fA14 i1="22"><s1>Department of Clinical Neuroscience, Royal Free Hospital Medical School</s1><s2>London</s2><s3>GBR</s3><sZ>23 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="23"><s1>National Hospital for Neurology and Neurosurgery</s1><s2>London</s2><s3>GBR</s3><sZ>23 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2007">2007</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Nervous system diseases</term><term>Parkinson disease</term><term>Quality of life</term><term>Questionnaire</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Pathologie du système nerveux</term><term>Maladie de Parkinson</term><term>Questionnaire</term><term>Qualité de vie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Non-motor symptoms (NMS) in Parkinson's disease (PD) are common, significantly reduce quality of life and at present there is no validated clinical tool to assess the progress or potential response to treatment of NMS. A new 30-item scale for the assessment of NMS in PD (NMSS) was developed. NMSS contains nine dimensions: cardiovascular, sleep/fatigue, mood/cognition, perceptual problems, attention/memory, gastrointestinal, urinary, sexual function, and miscellany. The metric attributes of this instrument were analyzed. Data from 242 patients mean age 67.2 ±11 years, duration of disease 6.4 ± 6 years, and 57.3% male across all stages of PD were collected from the centers in Europe, USA, and Japan. The mean NMSS score was 56.5 ± 40.7, (range: 0-243) and only one declared no NMS. The scale provided 99.2% complete data for the analysis with the total score being free of floor and ceiling effect. Satisfactory scaling assumptions (multitrait scaling success rate >95% for all domains except miscellany) and internal consistency were reported for most of the domains (mean a, 0.61). Factor analysis supported the a prori nine domain structure (63% of the variance) while a small test-retest study showed satisfactory reproducibility (ICC > 0.80) for all domains except cardiovascular (ICC = 0.45). In terms of validity, the scale showed modest association with indicators of motor symptom severity and disease progression but a high correlation with other measures of NMS (NMSQuest) and health-related quality of life measure (PDQ-8) (both, rS = 0.70). In conclusion, NMSS can be used to assess the frequency and severity of NMS in PD patients across all stages in conjunction with the recently validated non-motor questionnaire.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Espagne</li><li>Israël</li><li>Italie</li><li>Japon</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Communauté de Madrid</li><li>Grand Londres</li><li>Géorgie (États-Unis)</li><li>Latium</li><li>Texas</li><li>État de New York</li></region><settlement><li>Londres</li><li>Madrid</li><li>Rome</li></settlement></list><tree><noCountry><name sortKey="Forbes, Alison" sort="Forbes, Alison" uniqKey="Forbes A" first="Alison" last="Forbes">Alison Forbes</name></noCountry><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Ray Chaudhuri, Kallol" sort="Ray Chaudhuri, Kallol" uniqKey="Ray Chaudhuri K" first="Kallol" last="Ray Chaudhuri">Kallol Ray Chaudhuri</name></region><name sortKey="Breen, Kieran" sort="Breen, Kieran" uniqKey="Breen K" first="Kieran" last="Breen">Kieran Breen</name><name sortKey="Brown, Richard G" sort="Brown, Richard G" uniqKey="Brown R" first="Richard G." last="Brown">Richard G. Brown</name><name sortKey="Hand, Annette" sort="Hand, Annette" uniqKey="Hand A" first="Annette" last="Hand">Annette Hand</name><name sortKey="Macmahon, Doug" sort="Macmahon, Doug" uniqKey="Macmahon D" first="Doug" last="Macmahon">Doug Macmahon</name><name sortKey="Macphee, Graeme" sort="Macphee, Graeme" uniqKey="Macphee G" first="Graeme" last="Macphee">Graeme Macphee</name><name sortKey="Naidu, Yogini" sort="Naidu, Yogini" uniqKey="Naidu Y" first="Yogini" last="Naidu">Yogini Naidu</name><name sortKey="Ray Chaudhuri, Kallol" sort="Ray Chaudhuri, Kallol" uniqKey="Ray Chaudhuri K" first="Kallol" last="Ray Chaudhuri">Kallol Ray Chaudhuri</name><name sortKey="Ray Chaudhuri, Kallol" sort="Ray Chaudhuri, Kallol" uniqKey="Ray Chaudhuri K" first="Kallol" last="Ray Chaudhuri">Kallol Ray Chaudhuri</name><name sortKey="Schapira, Anthony H V" sort="Schapira, Anthony H V" uniqKey="Schapira A" first="Anthony H. V." last="Schapira">Anthony H. V. Schapira</name><name sortKey="Schapira, Anthony H V" sort="Schapira, Anthony H V" uniqKey="Schapira A" first="Anthony H. V." last="Schapira">Anthony H. V. Schapira</name><name sortKey="Thomas, Sue" sort="Thomas, Sue" uniqKey="Thomas S" first="Sue" last="Thomas">Sue Thomas</name><name sortKey="Tluk, Susanne" sort="Tluk, Susanne" uniqKey="Tluk S" first="Susanne" last="Tluk">Susanne Tluk</name><name sortKey="Williams, Adrian J" sort="Williams, Adrian J" uniqKey="Williams A" first="Adrian J." last="Williams">Adrian J. Williams</name></country><country name="Espagne"><region name="Communauté de Madrid"><name sortKey="Martinez Martin, Pablo" sort="Martinez Martin, Pablo" uniqKey="Martinez Martin P" first="Pablo" last="Martinez-Martin">Pablo Martinez-Martin</name></region></country><country name="États-Unis"><noRegion><name sortKey="Sethi, Kapil" sort="Sethi, Kapil" uniqKey="Sethi K" first="Kapil" last="Sethi">Kapil Sethi</name></noRegion><name sortKey="Olanow, Warren" sort="Olanow, Warren" uniqKey="Olanow W" first="Warren" last="Olanow">Warren Olanow</name><name sortKey="Ondo, William" sort="Ondo, William" uniqKey="Ondo W" first="William" last="Ondo">William Ondo</name><name sortKey="Rye, David" sort="Rye, David" uniqKey="Rye D" first="David" last="Rye">David Rye</name></country><country name="Italie"><region name="Latium"><name sortKey="Stocchi, Fabrizio" sort="Stocchi, Fabrizio" uniqKey="Stocchi F" first="Fabrizio" last="Stocchi">Fabrizio Stocchi</name></region><name sortKey="Barone, Paolo" sort="Barone, Paolo" uniqKey="Barone P" first="Paolo" last="Barone">Paolo Barone</name></country><country name="Allemagne"><noRegion><name sortKey="Odin, Per" sort="Odin, Per" uniqKey="Odin P" first="Per" last="Odin">Per Odin</name></noRegion></country><country name="Japon"><noRegion><name sortKey="Abe, Kazu" sort="Abe, Kazu" uniqKey="Abe K" first="Kazu" last="Abe">Kazu Abe</name></noRegion><name sortKey="Tsuboi, Yoshio" sort="Tsuboi, Yoshio" uniqKey="Tsuboi Y" first="Yoshio" last="Tsuboi">Yoshio Tsuboi</name></country><country name="Israël"><noRegion><name sortKey="Rabey, Martin" sort="Rabey, Martin" uniqKey="Rabey M" first="Martin" last="Rabey">Martin Rabey</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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